Abstract:

The proposed fourcompartment mathematical model describes transport kinetics of 99m-technetium radiotracers at intravenous administration process with taking into account radiopharmaceutical accumulation, elimination and radioactive decay. The analytical solution of the model in a form of the well-known sum-of exponential solution was obtained. The dependencies of the tracer concentration versus the time are analyzed. The model can be easily verified by the radioactive tracer concentration data in the circulatory/lymphatic system measured at some time points, and the obtained data can be used to determine the transport coefficients. Time-activity dependencies were obtained and analyzed for each compartment. The model can be used for individual transport parameter calculation at administration of diagnostic/therapeutic dose loads.

Keywords: Radiotracers, circulatory system, lymphatic system, transport kinetics of radiotracers, mathematical model.